Neuroendocrinology
Rapid Communications
Interleukin-1 Directly Stimulates the Release of Corticotrophin Releasing Factor from Rat HypothalamusTsagarakis S.a · Gillies G.b · Rees L.H.c · Besser M.a · Grossman A.aDepartments of aEndocrinology and cChemical Endocrinology, and bProtein Hormone Unit, St. Bartholomew’s Hospital, London, UK
Keywords: Interleukin-1CRF-41HypothalamusACTH |
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Article / Publication Details
Received: June 21, 1988
Accepted: October 03, 1988
Published online: April 02, 2008
Issue release date: 1989
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
While interleukin-1 (IL-1), a monocyte-derived polypeptide, clearly stimulates the hypothalamo-pituitary-adrenal (HPA) axis, its precise site of action is controversial. In these studies, the possibility of a hypothalamic and/or a pituitary site of action was investigated in vitro, using incubated rat hypothalami and perifused dispersed pituitary cells. Both forms of IL-1, IL-1α and IL-1β, produced a dose-dependent stimulation of CRF-41 release from incubated rat hypothalami in the dose range of 1–100 U/ml (p < 0.01). However, concentrations of both interleukins of 1–1,000 U/ml given as 10-min infusions had no effect on ACTH release from dispersed pituitary cells. Moreover, IL-1β, used in the concentration range of 1–100 U/ml, was unable to potentiate CRF-41-induced ACTH release. These data therefore provide evidence that at least the acute stimulatory effects of IL-1 on the HPA axis are predominantly mediated via a direct stimulation of hypothalamic CRF-41, suggesting that the hypothalamus may provide an interface between the neuroendocrine and immune axes.
© 1989 S. Karger AG, Basel
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Article / Publication Details
Received: June 21, 1988
Accepted: October 03, 1988
Published online: April 02, 2008
Issue release date: 1989
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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