Neuroendocrinology

Original Paper

Reduction in Testicular Function in Rats

II. Reduction by Dexamethasone in Fetal and Neonatal Rats
Lalau J.-D.a · Aubert M.L.b · Carmignac D.F.b · Grégoire I.a · Dupouy J.-P.c

Author affiliations

aLaboratoire de Physiologie animale, Faculté des Sciences d’Amiens, France; bDivision de Biologie de la Croissance et de la Reproduction, Département de Pédiatrie, Faculté de Médecine, Genève, Suisse; cLaboratoire de Neuroendocrinologie du Développement, Université de Lille 1, Villeneuve d’Ascq, France

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Neuroendocrinology 1990;51:289–293

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 28, 1988
Accepted: July 27, 1989
Published online: April 03, 2008
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN

Abstract

Chronic administration of dexamethasone in drinking water to maternal rats from days 15 to 21 of gestation (1) reduced plasma testosterone concentrations in male fetuses between days 19 and 21 but not earlier on day 18 and abolished the prenatal peak of plasma testosterone which normally occurs on day 19 of gestation, and (2) suppressed the postnatal surge of plasma testosterone in male newborns 1.5 and 2 h after delivery at term by cesarean section. The administration of dexamethasone to male fetuses at birth induced 1 h later a slight but not significant increase in hypothalamic gonadotropin-releasing hormone (GnRH) and pituitary luteinizing hormone (LH) contents, reduced drastically plasma LH levels and completely prevented the postnatal surge of plasma testosterone which occurred normally in littermate controls. A rise in pituitary LH content, and a sharp reduction in plasma LH and testosterone concentrations were noted in 19-day-old male fetuses whose mothers were acutely treated with dexamethasone on day 18 of gestation. Similar evolutions for LH were observed in littermate females. These results suggest that the inhibitory effects of exogenous glucocorticoids on testosterone secretion could be mediated in both fetuses and newborns at least partially through suppression of the hypothalamic and pituitary secretion of GnRH and LH, respectively, and provide insight how stress or hormone imbalance may affect the development of this neuroendocrine system.

© 1990 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 28, 1988
Accepted: July 27, 1989
Published online: April 03, 2008
Issue release date: 1990

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN


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