Neuroendocrinology
Original Paper
Opioid Receptor Subtype Involvement in Maternal Behavior in Lactating RatsMann P.E. · Kinsley C.H. · Bridges R.S.Laboratory of Human Reproduction and Reproductive Biology, Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Mass., USA
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Article / Publication Details
Received: June 07, 1990
Accepted: October 10, 1990
Published online: April 04, 2008
Issue release date: 1991
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
Central or systemic administration of morphine disrupts maternal behavior in steroid-primed, pup-induced virgin and lactating rats. Morphine, the prototypical µ agonist, also interacts with different opioid receptor subtypes. The present study examined the effectiveness of five receptor-selective agonists, in addition to morphine, to disrupt maternal behavior in primiparous lactating rats following intracerebroventricular (i.c.v.) infusions in order to characterize opioid receptor subtype involvement in maternal behavior in the female rat. Virgin, Sprague-Dawley rats were mated and implanted with lateral ventricle cannulae on days 13–15 of gestation. On postpartum day 5, mothers were tested for maternal behavior 30 min after i.c.v. vehicle infusion (5 µl). On day 6, rats received one of the following opioid receptor agonists 30 min before testing: β-endorphin (µ/Ε receptor subtype; 0.29, 0.72, 1.45, 2.9 nmol), DAGO (µ; 0.29, 0.72, 1.45, 2.9 nmol), morphine (µ; 0.29, 0.72, 1.45, 2.9, 14.5 nmol), DPDPE (δ; 2.9, 29 nmol), U50488H (ĸ1; 2.9, 29, 145 nmol) and SKF10047 (σ; 2.9, 29, 145 nmol). Only activation of µ opioid receptors dose-dependently disrupted maternal behavior in primiparous lactating rats. DPDPE, U50488 and SKF10047 had no discernible effect on maternal behavior. DAGO, a highly selective µ agonist, was even more potent than β-endorphin and morphine in disrupting maternal behavior suggesting that maternal behavior is regulated by opioids interacting with the µ opioid receptor.
© 1991 S. Karger AG, Basel
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Article / Publication Details
Received: June 07, 1990
Accepted: October 10, 1990
Published online: April 04, 2008
Issue release date: 1991
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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