Neuroendocrinology
Original Paper
Ultrastructural Evidence of a Sexual Dimorphism in the Neuropil of the Medial Preoptic Nucleus of the Rat: A Quantitative StudyLarriva-Sahd J.Experimental Pathology Laboratory, Department of Pathology, National Institute of Nutrition, Mexico City, Mexico
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Article / Publication Details
Received: October 05, 1990
Accepted: March 01, 1991
Published online: April 07, 2008
Issue release date: 1991
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
In the rat, a new structural sex difference of the nervous system was found: the density of axodendritic synapses (ADS) is larger in the male central component of the medial preoptic nucleus (MPNc), as proven by quantitative electron microscopy. The study included 24 animals divided into four groups (n = 6): control males (CM), control females (CF), males castrated as newborn (MGx) and males castrated as newborn and treated 10 days with daily injections of testosterone. No significant differences were found in the number of axospinous synapses among all groups; however, the number of ADS was significantly larger in CM when compared to that of the CF. This difference was abrogated by castration of the newborn male and restored by perinatal treatment with testosterone. Further, no difference in ADS was encountered between CF and MGx. The present data, together with previous studies which indicate that sex steroids do modify the number of synapses in other nuclei of the brain, led us to conclude that the sex difference in the number of ADS within the MPNc is determined by the organizational effect(s) of testosterone.
© 1991 S. Karger AG, Basel
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Article / Publication Details
Received: October 05, 1990
Accepted: March 01, 1991
Published online: April 07, 2008
Issue release date: 1991
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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