Metabolomics: A Complementary Tool in Renal TransplantationWishart D.
Departments of Biological Sciences and Computing Science, University of Alberta, National Research Council, National Institute for Nanotechnology, Edmonton, Alta., Canada
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Renal transplant success is closely tied to the ability to monitor transplant recipients and responsively change their medications. However, transplant monitoring still depends on relatively dated technologies - serum creatinine levels, urine output, and histopathology of biopsy samples. These techniques do not offer sufficient specificity, sensitivity, or accuracy for appropriate and timely interventions. As a result, more specific diagnostic techniques, based on proteomics, genomics and metabolomics are being sought. Metabolomics (the high-throughput measurement and analysis of metabolites) may make it possible to monitor transplants more effectively and specifically. Changes in the concentration profiles of a number of small molecule metabolites found in either blood or urine can be used to localize kidney damage, assess organs at risk of rejection, assess kidneys suffering from ischemiareperfusion injury or identify organs that have been damaged by immunosuppressive drugs. The application of metabolomics to kidney transplant monitoring is still in its early stages. Nevertheless, there are a number of easily measured metabolites in both urine and serum that can provide reliable indications of kidney function, kidney injury, and immunosuppressive drug toxicity. Metabolomics could serve as a good complement to existing proteomic and genomic technologies.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.