Neuroendocrinology
Original Paper
Sex Differences in the Regulation of Oxytocin Receptors by Ovarian Steroids in the Ventromedial Hypothalamus of the RatCoirini H.a · Johnson A.E.b · Schumacher M.a · McEwen B.S.aLaboratory of Neuroendocrinology, The Rockefeller University, New York, N.Y.; Section on Comparative Studies of Brain and Behavior, Laboratory of Clinical Sciences, National Institutes of Mental Health, Poolesville, Md., USA
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Article / Publication Details
Received: March 01, 1991
Accepted: June 25, 1991
Published online: April 07, 2008
Issue release date: 1992
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
Abstract
The facilitation of sexual receptivity by oxytocin (OT) in female rats is related to the regulation of oxytocin receptors (OTR) by ovarian steroids in the ventromedial nuclei (VMN) of the hypothalamus. In a previous study, we have shown that estradiol benzoate (EB) causes a twofold increase in OTR binding in the VMN. Progesterone (P) then modulates levels of the estrogen-induced OTR and increases the area occupied by the receptors by acting on the neuronal membrane. In the present study, we compared the effects of EB and P on OTR binding between males and females. In both sexes, EB increased the density of OTR and the area covered by the receptors at the level of the medial and caudal VMN. In estrogen-primed females, P further increased OTR levels in the medial VMN and the area covered by OTR at the level of the caudal VMN. By contrast, P did not modulate OTR binding in estrogen-primed males. Thus, the behavioral insensitivity of male rats to ovarian hormones, in particular to P, may be related to sex differences affecting the modulation of OTR binding.
© 1992 S. Karger AG, Basel
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Article / Publication Details
Received: March 01, 1991
Accepted: June 25, 1991
Published online: April 07, 2008
Issue release date: 1992
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)
For additional information: https://www.karger.com/NEN
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