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Original Paper

Postnatal Development of Corticosteroid Receptor Immunoreactivity in the Rat Cerebellum and Brain Stem

Lawson A.a,b · Ahima R.S.a · Krozowski Z.c · Harlan R.E.a,d

Author affiliations

aDepartment of Anatomy and dNeuroscience Training Program, Tulane University School of Medicine, New Orleans, La., USA; bDepartment of Anatomy, University of Ghana Medical School, Accra, Ghana; cBaker Medical Institute, Prahan, Australia

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Neuroendocrinology 1992;55:695–707

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 11, 1991
Accepted: September 12, 1991
Published online: April 07, 2008
Issue release date: 1992

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN

Abstract

The postnatal development of corticosteroid receptor immunoreactivity in the rat cerebellum and related brainstem nuclei was studied using a type I receptor antiserum, MINREC4, and a type II receptor monoclonal antibody, BUGR2. Type I receptor immunoreactive (ir) Purkinje cells were first observed at postnatal day 5 (P5), and increased to adult levels by P20.Type I-ir cells, presumably migrating granule cells, were observed in the developing molecular layer of the cerebellum at P5. By P30, the density of type I-ir cells in the definitive molecular and granular layers was still less than adult levels. In contrast, type II-ir Purkinje cells were first observed at PI5 and increased to adult levels by P20. No type II-ir cells were observed in the proliferative and migratory zones of the molecular layer. By P30, the density of type II-ir cells in the molecular and granular layers was far less than adult levels. In the deep cerebellar nuclei and most brain stem nuclei type I-ir was observed at P5 and developed to adult levels by P30. Type II-ir was observed in the deep cerebellar nuclei, red and medial vestibular nuclei by P15. The pontine and inferior olivary nuclei showed type II-ir cells by P10. Type II-ir in these regions developed to adult levels by P30. The earlier development of type I-ir suggests that the type I receptor may mediate the actions of corticosteroids in the cerebellum and related brain stem nuclei during early postnatal life. Both type I and type II corticosteroid receptors may mediate corticosteroid effects in the cerebellum and brain stem nuclei during late postnatal life and adulthood.

© 1992 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 11, 1991
Accepted: September 12, 1991
Published online: April 07, 2008
Issue release date: 1992

Number of Print Pages: 13
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN


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