Neuroendocrinology

Prolactin and Lactation

Central Effects of Catecholamines upon Mammary Contractility in Rats Are Neurally Mediated

Mena F. · Aguayo D. · Pacheco P. · Morales M.T.

Author affiliations

Departamento de Fisiología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México, D.F., México

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Neuroendocrinology 1995;61:722–730

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Article / Publication Details

First-Page Preview
Abstract of Prolactin and Lactation

Received: February 24, 1994
Accepted: January 05, 1995
Published online: April 09, 2008
Issue release date: 1995

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN

Abstract

We injected, i.e., intracerebroventricularly (ICV) or systematically, small amounts of adrenaline (ADR), noradrenaline (NA), isoproterenol (ISOP) and dopamine (DA) in urethane-anesthetized lactating rats, and determined the effects on isometrically recorded intramammary pressure (IMP) responses to exogenous oxytocin (OXY). While centrally administered ADR, NA and DA provoked increased IMP responses to OXY, the β-adrenergic agonist ISOP induced the opposite effect. These effects were reversible, dose related and also occurred in hypophysectomized rats. However, when injected systematically, all adrenergic agonists but DA depressed IMP responses to OXY. Further experiments showed that central effects of catecholamines were exerted by regulating ductal tone, through the direct innervation of the mammary glands. Thus, whereas complete blockage of these effects occurred after selective denervation of the mammary glands, increased ductal tone resulted from ICV administration of ISOP. Finally, evidence was also obtained that antagonistic α- and β-adrenergic mechanisms may interact with each other to regulate milk ejection, and with afferent signals from the mammary glands. Thus, β-adrenergic inhibition upon IMP was counteracted by either NA administration or by activation of ductal mechanoreceptors. Together, these results suggest that regulation of milk ejection may involve neurally mediated influences on mammary contractility. Such actions would interact closely with afferents from the mammary gland influencing ductal tone.

© 1995 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Prolactin and Lactation

Received: February 24, 1994
Accepted: January 05, 1995
Published online: April 09, 2008
Issue release date: 1995

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: https://www.karger.com/NEN


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