European Surgical Research

 

Physiologic Studies during Perfusion of the Isolated Canine Pancreas

The Endocrine and Exocrine Behavior
Meyer W. · Castelfranchi P.L. · Schulz L.S. · Ruiz O.J. · Hendrickx J. · Aquino C.J. · Lillehei R.C.

Author affiliations

University Hospitals, Department of Surgery, Düsseldorf, Germany, and Minnesota University Hospitals, Minneapolis, Minn., USA

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Eur Surg Res 1973;5:105–115

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: April 27, 1972
Accepted: August 21, 1972
Published online: April 15, 2008
Issue release date: 1973

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

The canine pancreas-duodenum has been perfused for 3 h with a membrane oxygenator, a pulsatile pump and a heat exchanger at a temperature of 37 °C. Among the criteria used in this study, the insulin output into the venous blood in response to glucose administration, as well as pancreas secretion after secretin stimulation were those found to be the most reliable indicators as to the viability of the pancreas. This is further supported by an average oxygen consumption of 0.77 ml O2/100 g at a constant flow of 80 ml/min and a perfusion pressure of 75 mm Hg. The pressure/flow relationship as for any other perfused organ was a safe indicator as to the viability of the perfused pancreas. The functional viability correlated with our anatomical findings.

© 1973 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: April 27, 1972
Accepted: August 21, 1972
Published online: April 15, 2008
Issue release date: 1973

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR


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