European Surgical Research
Physiologic Studies during Perfusion of the Isolated Canine PancreasThe Endocrine and Exocrine Behavior
Meyer W. · Castelfranchi P.L. · Schulz L.S. · Ruiz O.J. · Hendrickx J. · Aquino C.J. · Lillehei R.C.
University Hospitals, Department of Surgery, Düsseldorf, Germany, and Minnesota University Hospitals, Minneapolis, Minn., USA
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Article / Publication Details
Received: April 27, 1972
Accepted: August 21, 1972
Published online: April 15, 2008
Issue release date: 1973
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
Abstract
The canine pancreas-duodenum has been perfused for 3 h with a membrane oxygenator, a pulsatile pump and a heat exchanger at a temperature of 37 °C. Among the criteria used in this study, the insulin output into the venous blood in response to glucose administration, as well as pancreas secretion after secretin stimulation were those found to be the most reliable indicators as to the viability of the pancreas. This is further supported by an average oxygen consumption of 0.77 ml O2/100 g at a constant flow of 80 ml/min and a perfusion pressure of 75 mm Hg. The pressure/flow relationship as for any other perfused organ was a safe indicator as to the viability of the perfused pancreas. The functional viability correlated with our anatomical findings.
© 1973 S. Karger AG, Basel
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Article / Publication Details
Received: April 27, 1972
Accepted: August 21, 1972
Published online: April 15, 2008
Issue release date: 1973
Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
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