European Surgical Research
Hepatic Arterial and Portal Venous Flows during HemorrhageDarle N. · Lim, jr. R.C.Trauma .Center and Surgical Service of the University of California, School of Medicine, San Francisco General Hospital, San Francisco, Calif.
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Article / Publication Details
Received: November 19, 1974
Accepted: February 13, 1975
Published online: April 15, 2008
Issue release date: 1975
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
Abstract
Changes of total liver blood flow (TLBF), portal venous and hepatic arterial flows have been investigated using a hemorrhagic model in dogs. The dogs were bled stepwise from normal blood pressure to a pressure of 50–60 mm Hg. TLBF was measured by the xenon clearance method. Hepatic arterial blood flow was measured by electromagnetic flowmeter. Portal venous flow was calculated by subtracting hepatic arterial blood flow from TLBF. Other parameters studied during the experiment were systemic arterial blood pressure and portal venous pressure. Under normotensive conditions TLBF in mean was registered as 127 ml/min × 100 g liver tissue (25 ml/min × kg body weight). The relation between the flow value in portal vein and hepatic artery was on average 2.3:1. The study shows that there was a pronounced decrease of TLBF flow during hemorrhage. Portal venous flow decreased almost parallel to TLBF, while hepatic arterial flow decreased to a lesser extent which means that there was autoregulation in this flow bed. Hepatic arterial flow successively constituted a larger part of TLBF, during hemorrhage sometimes 65% compared to the normal value of about 30%. During the study there was an increase of vascular resistance in the portal venous system and decreased resistance in the hepatic arterial bed.
© 1975 S. Karger AG, Basel
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Article / Publication Details
Received: November 19, 1974
Accepted: February 13, 1975
Published online: April 15, 2008
Issue release date: 1975
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
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