European Surgical Research
Sulfinpyrazone and Postoperative Deep Vein ThrombosisGruber U.F. · Buser P. · Frick J. · Loosli J. · Matt E. · Segesser D.Department of Surgery, University of Basel
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Article / Publication Details
Received: February 07, 1977
Accepted: May 23, 1977
Published online: April 16, 2008
Issue release date: 1977
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
Abstract
Small doses of subcutaneous heparin and infusions of dextran both reduce the incidence of fatal pulmonary embolism after elective general surgery. But both methods have disadvantages. Therefore, the protection against deep vein thrombosis afforded by sulfínpyrazone, a drug which can be taken by mouth as well as by injection, was assessed in a prospective study of 119 patients undergoing elective general or urological surgery. The prophylactic administration of sulfínpyrazone was compared with the effects of small doses of sodium heparin and infusions of dextran-70. The 125I-fibrinogen test was carried out in all patients during their hospitalization. Deep vein thrombosis was diagnosed in 13 of 30 patients (43%) who received sulfínpyrazone, in 9 of 29 (31%) receiving dextran-70 and in 2 of 22 (9%) having subcutaneous heparin. The difference between the sulfínpyrazone and heparin groups was statistically significant (p < 0.01). Sulfínpyrazone in the dose used in this trial was not effective in reducing the incidence of deep vein thrombosis during elective general surgery.
© 1977 S. Karger AG, Basel
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Article / Publication Details
Received: February 07, 1977
Accepted: May 23, 1977
Published online: April 16, 2008
Issue release date: 1977
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)
For additional information: https://www.karger.com/ESR
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