European Surgical Research

Original Paper

Altered Portal Pressure Secondary to Portacaval and Portasystemic Shunts in the Rat: The Effect on Liver Function and Intestinal Integrity

Hess F. · Jerusalem C. · Willemen A.

Author affiliations

Laboratory for Cytology and Histology, Catholic University of Nijmegen, The Netherlands

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Eur Surg Res 1982;14:286–297

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 03, 1981
Accepted: December 11, 1981
Published online: April 18, 2008
Issue release date: 1982

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR

Abstract

Two types of portasystemic shunts were investigated in the rat: low pressure shunts (portacaval shunt, PCS, and portacaval transposition, PCT) and high pressure shunts (portasystemic shunt by ligation of the portal vein after splenic transposition, PSSL). Liver atrophy was seen in all groups but PCT. Simplification of intestinal villi was observed in all groups and related to the degree of portal pressure alteration. Liver function and clinical status improved if some blood, either systemic or splanchnic, perfused the liver through surgical deviation (PCT) or accidental collateral formation (PSSL + C). In the prevention of the PCS syndrome selective portacaval shunting is advocated, leaving some blood to flow to the liver. A high as possible splanchnic pressure prevents intestinal villi simplification and loss of resorptional surface.

© 1982 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 03, 1981
Accepted: December 11, 1981
Published online: April 18, 2008
Issue release date: 1982

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 0014-312X (Print)
eISSN: 1421-9921 (Online)

For additional information: https://www.karger.com/ESR


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