Cellular Physiology and Biochemistry

Original Paper

Free Access

Characterization and Comparison of Na+, K+ and Ca2+ Currents Between Myocytes from Human Atrial Right Appendage and Atrial Septum

Gong D.a,d · Zhang Y.a · Cai B.a · Meng Q.b · Jiang S.b · Li X.c · Shan L.a · Liu Y.a · Qiao G.a · Lu Y.a,d · Yang B.a,d

Author affiliations

aDepartment of Pharmacology; bDepartment of Cardiac Surgery, the 2nd Affiliated Hospital; cDepartment of Bioinformatics, and dState-Province Key Laboratories of Biomedicine Pharmaceutics, Harbin Medical University, Harbin

Corresponding Author

Baofeng Yang

Department of Pharmacology, Harbin Medical University

Baojian Road 157, Harbin, Heilongjiang 150081 (P. R. China)

Tel. +86 451 86671354, Fax: +86 451 86675769

E-Mail yangbf@ems.hrbmu.edu.cn

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Cell Physiol Biochem 2008;21:385–394

Abstract

Atrial pacing to reduce paroxysmal atrial fibrillation recurrences is performed in right atrial appendage (RAA) traditionally. However, recent studies indicate that atrial septal (AS) pacing produces better outcomes than the RAA pacing. The underlying mechanisms for this difference remained unclear. One possible explanation for the superiority of AS pacing over RAA pacing is that the two different regions have distinct electrophysiological properties. The study was to explore whether there indeed exist regional differences of electrical activities between RAA and AS, using whole-cell patch clamp techniques. The results showed that RAA cells had longer action potential duration, more negative resting potential and greater amplitude of action potential, whereas AS cells had more rapid depolarizing velocity. The sodium current was significantly smaller in RAA cells, whereas the calcium current was markedly smaller in AS cells. The transient outward K+ current was similar in both regions. The ultrarapid delayed rectifier K+ current was greater in RAA than that in AS cells. The inward rectifier K+ current was similar at potentials more negative to -60 mV in both regions. The results indicate that RAA and AS of patients with rheumatic heart disease possess distinct electrophysiological properties. These differences provided a rational explanation for the different efficacies in treating atrial fibrillation by atrial pacing in RAA and AS regions.

© 2008 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Accepted: January 03, 2008
Published online: April 24, 2008
Issue release date: April 2008

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-8987 (Print)
eISSN: 1421-9778 (Online)

For additional information: https://www.karger.com/CPB


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