Cytogenetic and Genome Research

 

Meiotic nondisjunction in mice and mouse hybrids

Tettenborn U. · Gropp A.

Author affiliations

Institute of Pathology, University of Bonn, Bonn-Venusberg

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Cytogenetics 1970;9:272–283

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Article / Publication Details

First-Page Preview
Abstract of Paper

Accepted: October 23, 1969
Published online: April 30, 2008
Issue release date: 1970

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Nondisjunction in the first meiotic division was evaluated by the frequency of aneuploid metaphase II (M II) figures in secondary spermatocytes of Mus musculus (N = 40; FN = 40), M. poschiaυinus (N = 26; FN = 40) and M. musculus × M. poschiavinus F1-hybrids (N = 33; FN = 40), whose karyotypes are related by Robertsonian-type centric fusions. Regular anaphase I disjunction prevailed in M. musculus and M. poschiavinus, where 92.8% and 94.0% of the M II figures examined had a complete haploid chromosome complement. In the F1-hybrids, however, less than one half of the M II figures examined were euploid (FN/2 = 20), whereas the frequency of hypomodal (FN/2 = 15 to 19; 31.2%) and hypermodal (FN/2 = 21 to 25; 24.2%) was high. These results emphasize the importance of the heterozygous state, and particularly structural heterozygosity within a Robertsonian system of karyotypic variation, in inducing meiotic nondisjunction. From the standpoint of methodology, M. musculus × M. poschiavinus hybrids of different generations should make possible stepwise analysis of the involvement of specific chromosomes in meiotic nondisjunction.

© 1970 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Paper

Accepted: October 23, 1969
Published online: April 30, 2008
Issue release date: 1970

Number of Print Pages: 12
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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