Dermatologic Immunity
Editor(s): Nickoloff, B.J. (Chicago, IL)Nestle, F.O. (London)
Cutaneous Lupus Erythematosus: Molecular and Cellular Basis of Clinical FindingsKuhn A.a ยท Sontheimer R.baDivision of Immunogenetics, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany; b Department of Dermatology, University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA
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Article / Publication Details
Published online: May 07, 2008
Cover Date: 2008
Number of Print Pages: 22
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)
Abstract
Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune disease with welldefined skin lesions, including acute CLE, subacute CLE, chronic CLE and intermittent CLE. In the first part of the review, we discuss the variable relationships that exist between the different clinical forms of CLE and the risk of systemic disease activity. Furthermore, we focus on the annular and papulosquamous forms of subacute CLE and emphasize dermal scarring as a characteristic feature of chronic discoid skin disease in contrast to other subtypes of CLE. Various environmental factors influence the clinical expression of CLE and a striking relationship has emerged between sunlight exposure and the various subtypes of this disease. In the second part, we review the evidence for the abnormal long-lasting photoreactivity in CLE, with an overview of the molecular and cellular factors that may underlie this abnormality. In particular, we discuss the role of UV-mediated induction of apoptosis, mediators of inflammation, such as cytokines and chemokines, nitric oxide, T cell-mediated injury, and the influence of regulatory CD4+CD25+ T cells. However, a complete understanding of the diverse pathophysiologic mechanisms and interactions in CLE does not exist and, as there is yet no convincing animal model of CLE, many studies remain descriptive in nature.
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Article / Publication Details
Published online: May 07, 2008
Cover Date: 2008
Number of Print Pages: 22
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8391-6 (Print)
eISBN: 978-3-8055-8392-3 (Online)
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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