Cytogenetic and Genome Research

SCE and Chromosomal Mutation I

Difficulties in assessing the human health effects of mutagenic carcinogens by cytogenetic analyses

Wolff S.

Author affiliations

Laboratory of Radiobiology and Environmental Health and Department of Anatomy, University of California, San Francisco, San Francisco, Calif.

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Cytogenet Cell Genet 1982;33:7–13

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Article / Publication Details

First-Page Preview
Abstract of SCE and Chromosomal Mutation I

Published online: May 07, 2008
Issue release date: 1982

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

The analysis of induced chromosome aberrations in the peripheral lymphocytes of irradiated people is a reliable method for determining exposure to ionizing radiations. The system should also work for S-independent chemicals. For the majority of chemical clastogens, which are S-dependent, however, the utility of the system is far less certain because DNA repair can remove many of the adducts before the cells enter S. Sister chromatid exchanges are sensitive indicators of S-dependent mutagens; however, because of DNA repair, great interpersonal variability of response, and variability of reference populations, it has not yet been proved that they can be used to monitor populations for low-level chronic exposure. In any case, these cytogenetic tests can only be used to estimate the risk to the population as a whole. They cannot be used to predict whether a given person will suffer any particular form of ill health.

© 1982 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of SCE and Chromosomal Mutation I

Published online: May 07, 2008
Issue release date: 1982

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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