Original Research Article
Cerebral Metabolic Dysfunction in Patients with Dementia with Lewy Bodies and Visual HallucinationsPerneczky R.a · Drzezga A.b · Boecker H.b, d · Förstl H.a · Kurz A.a · Häussermann P.c, e
Departments of aPsychiatry and Psychotherapy, bNuclear Medicine and cNeurology, Technical University Munich, Munich, dDepartment of Radiology, Rheinische Friedrich Wilhelms University Bonn, Bonn, and eCentre for Integrative Psychiatry, Kiel, Germany
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Aims: To identify the pattern of cerebral hypometabolism in patients with dementia with Lewy bodies (DLB) and visual hallucinations (VH). Methods: Fourteen patients with DLB and VH, 7 with DLB without VH and 16 healthy controls underwent clinical and 18F-FDG PET evaluations. The 2 patient groups did not significantly differ in their clinical characteristics, except in the occurrence of VH. A voxel-wise comparison of 18F-FDG PET scans was conducted between each of the 2 patient groups and the control group, and the patient groups among each other. Results: Compared with the control group, hypometabolic regions were more extensive and confluent in the patient group with VH than in the group without VH. The direct comparison between the 2 patient groups revealed a significant metabolic deficit in the group with VH at the right occipito-temporal junction and the right middle frontal gyrus. Conclusions: These results suggest that hypometabolism in visual association areas rather than the primary visual cortex is involved in VH in DLB.
© 2008 S. Karger AG, Basel
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