A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17pl3Schwartz C.E.a · McNally E.b · Leinwand L.b · Skolnick M.H.c
aRecombinant DNA Laboratory, Greenwood Genetic Center, Greenwood, SC, bDepartments of Microbiology and Immunology and of Genetics, Albert Einstein College of Medicine, Bronx, NY, and cDepartment of Medical Informatics, University of Utah Medical Center, Salt Lake City, UT
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Restriction fragment length polymorphisms (RFLPs) have been developed for an adult human skeletal muscle myosin heavy chain gene which was previously mapped to the short arm of human chromosome 17. Using RFLP analysis of DNA from 140 individuals, we have found tight linkage (LOD score of 6.9) between this myosin heavy chain gene and the anonymous DNA probe, D17S1.
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