The terminal deoxynucleotidyltransferase gene is located on human chromosome 10 (10q23→q24) and on mouse chromosome 19Yang-Feng T.L.a · Landau N.R.b · Baltimore D.b · Francke U.a
aDepartment of Human Genetics, Yale University School of Medicine, New Haven, CT, and bWhitehead Institute for Biomedical Research, Cambridge, MA, and Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA
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Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. Chromosomal assignment of the gene coding for human TdT was accomplished by in situ hybridization of a 3H-labeled cDNA probe to human chromosome preparations and by Southern blot analysis of somatic cell hybrid DNAs. The human TdT gene was mapped to the region q23→q24 of chromosome 10. Breaks at this site have been reported in different translocations in human leukemias. The mouse TdT gene was assigned to chromosome 19 by Southern blot analysis of mouse × Chinese hamster somatic cell hybrids. This result adds a fourth locus to the conserved syntenic group on mouse chromosome 19 and human chromosome 10.
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