Cytogenetic and Genome Research

Original Article

Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2and localization of the Down syndrome region on mouse chromosome 16

Reeves R.H.a · Gallahan D.b · O’Hara B.F.a · Callahan R.b · Gearhart J.D.a,c

Author affiliations

aDevelopmental Genetics Laboratory, Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, bLaboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD, and3 Departments of Cell Biology and Anatomy and of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD

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Cytogenet Cell Genet 1987;44:76–81

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: August 11, 1986
Published online: May 09, 2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Molecular probes were used as markers in the backcross (Czech II × BALB/cPt) × Czech II to determine the positions of six genes on mouse chromosome 16 (MMU 16). The order of the genes mapped is (centromere), protamine-1 (Prm-1), immunoglobulin λ1 light chain (Igl-1), preprosomatostatin (Smst), an endogenous mouse mammary tumor virus locus (Mtv-6), and two more distal sequences, superoxide dis-mutase, cytoplasmic form (Sod-1), and the proto-oncogene sequence Ets-2. The largest recombination frequency between any two adjacent markers is 24 cM, and thus the position of any marker on MMU 16 that is polymorphic between these two strains can be readily determined in this backcross. A region of MMU 16 which corresponds to the Down syndrome region of human chromosome 21 is located near the distal end of the chromosome.

© 1987 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: August 11, 1986
Published online: May 09, 2008
Issue release date: 1987

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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