Cytogenetic and Genome Research
Original Article
Genetic mapping of Prm-1, Igl-1, Smst, Mtv-6, Sod-1, and Ets-2and localization of the Down syndrome region on mouse chromosome 16Reeves R.H.a · Gallahan D.b · O’Hara B.F.a · Callahan R.b · Gearhart J.D.a,caDevelopmental Genetics Laboratory, Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD, bLaboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD, and3 Departments of Cell Biology and Anatomy and of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Accepted: August 11, 1986
Published online: May 09, 2008
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
Abstract
Molecular probes were used as markers in the backcross (Czech II × BALB/cPt) × Czech II to determine the positions of six genes on mouse chromosome 16 (MMU 16). The order of the genes mapped is (centromere), protamine-1 (Prm-1), immunoglobulin λ1 light chain (Igl-1), preprosomatostatin (Smst), an endogenous mouse mammary tumor virus locus (Mtv-6), and two more distal sequences, superoxide dis-mutase, cytoplasmic form (Sod-1), and the proto-oncogene sequence Ets-2. The largest recombination frequency between any two adjacent markers is 24 cM, and thus the position of any marker on MMU 16 that is polymorphic between these two strains can be readily determined in this backcross. A region of MMU 16 which corresponds to the Down syndrome region of human chromosome 21 is located near the distal end of the chromosome.
© 1987 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Accepted: August 11, 1986
Published online: May 09, 2008
Issue release date: 1987
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission