Cytogenetic and Genome Research

Original Article

Telomeric associations in a lymphoblastoid cell line from a patient with B-cell follicular lymphoma

Saltman D. · Ross F.M. · Fantes J.A. · Allshire R. · Turner G.E. · Evans H.J.

Author affiliations

Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh (UK)

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Cytogenet Cell Genet 1989;50:230–233

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: February 08, 1989
Published online: May 13, 2008
Issue release date: 1989

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

We have established a new Epstein-Barr virus transformed cell line from a patient with B-cell follicular lymphoma. Telomeric fusions were observed in several subclones, with the nonrandom involvement of chromosomes 1, 5, 12, and 17. Centromeric staining with immunofluorescent anti-kinetochore antibodies was positive in both centromeres of the fused chromosomes, suggesting they were both active. Unlike previously reported cases, we were unable to demonstrate telomeric fusions directly in cells from the patient’s blood. However, the finding of identical immunoglobulin gene rearrangements in DNA from the patient’s blood and cell line suggested that they originated from the same malignant B-cell clone.

© 1989 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Article

Accepted: February 08, 1989
Published online: May 13, 2008
Issue release date: 1989

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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