Gene Mapping, Cloning, and Sequencing
Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26→q28Tait J.F.a,b · Frankenberry D.A.a · Shiang R.c · Murray J.C.c · Adler D.A.b · Disteche C.M.b
Departments of aLaboratory Medicine and bPathology, University of Washington, Seattle, WA, and cDepartment of Pediatrics, University of Iowa, Iowa City, IA (USA)
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Annexin V is a member of a new family of calcium-dependent phospholipid-binding proteins. It has been previously isolated as placental anticoagulant protein I, inhibitor of blood coagulation, vascular anticoagulant-α, endonexin II, lipocortin V, placental protein 4, and anchorin CΠ. The human gene encoding annexin V (ANX5) was localized to 4q26→q28 by in situ hybridization with a cDNA probe and polymerase chain-reaction (PCR) analysis of a human × hamster hybrid cell panel. The regional localization to 4q26→q28 was supported by Southern-blot analysis of a human cell line with a deletion in 4q23→q27. This localization overlaps but differs slightly from the previous assignment of ANX5 to 4q28→q32. Digestion with Pvull and Taql identified polymorphisms at the ANX5 locus; the Pvull polymorphism could also be detected by PCR analysis.
© 1991 S. Karger AG, Basel
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