Gene Mapping, Cloning, and Sequencing
Localization of the human collagen gene COL7A1 to 3p21.3 by fluorescence in situ hybridizationGreenspan D.S.a · Byers M.G.b · Eddy R.L.b · Hoffman G.G.a · Shows T.B.b
aDepartment of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI, and bDepartment of Human Genetics, Roswell Park Memorial Institute, New York State Department of Health, Buffalo, NY (USA)
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An 8-kb genomic probe, containing 34 collagen-encoding exons, was localized to 3p21.3 by fluorescence in situ hybridization. The genomic probe encoded a previously uncharacterized carboxyl terminal portion of the αl(VII) collagen chain.This mapping result confirms the previous assignment of the αl(VII) gene (COL7A1) to 3p21 and offers a finer subregional localization than was previously available,
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