Cytogenetic and Genome Research
Gene Mapping, Cloning, and Sequencing
Localization of the gene encoding proteinase-3 (the Wegener’s granulomatosis autoantigen) to human chromosome band 19p13.3Sturrock A.B.a · Espinosa III R.b · Hoidal J.R.a · Le Beau M.M.baDivision of Pulmonary, Critical Care and Occupational Pulmonary Medicine, Department of Medicine, University of Utah, Salt Lake City, UT, and bThe Pritzker School of Medicine, University of Chicago Medical Center, Chicago, IL (USA)
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Article / Publication Details
Accepted: September 11, 1992
Published online: May 14, 2008
Issue release date: 1993
Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
Abstract
Proteinase-3 (PR3) is a polymorphonuclear leukocyte serine proteinase that is a potent inducer of emphysema in experimental models. PR3 is also the target antigen associated with Wegener’s granulomatosis. By analysis of a panel of somatic cell hybrids, the gene encoding PR3 was localized previously to chromosome 19; we have used fluorescence in situ hybridization to sublocalize this gene to 19p13.3.
© 1993 S. Karger AG, Basel
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Article / Publication Details
Accepted: September 11, 1992
Published online: May 14, 2008
Issue release date: 1993
Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
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