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Gene Mapping, Cloning, and Sequencing

Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens

Purrello M.a · Di Pietro C.a · Rapisarda A.b · Mirabile E.a · Motta S.b · Sichel G.a · Grzeschik K.-H.c

Author affiliations

aIstituto di Biologia generale and bDipartimento di Biologia animale e di Genetica, Università di Catania, Catania (Italy), and cMed. Zentrum für Humangenetik, Philipps Universität, Marburg (Germany)

Related Articles for ""

Cytogenet Cell Genet 1995;69:75–80

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: May 16, 1994
Published online: May 15, 2008
Issue release date: 1995

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

Analysis of loci GTF2F1 and GTF2B, encoding Rap 74 (a subunit of TFIIF) and TFIIB, respectively, showed that they are present in a single copy in the human genome and are localized at 19p13.3 and 1p22, respectively. By using as probe a cDNA for Rap 30 (the other subunit of TFIIF), we localized the GTF2F2 locus to 13q14; the same probe also detected a cross-hybridizing sequence at 4q31 whose functional importance remains to be elucidated. These data and those previously published by our group demonstrate that genes coding for class II general transcription factors with reported sequence similarity to bacterial sigma proteins are scattered in different regions of the human genome, with no evidence of clustering. This dispersion and the identification of homologs of both TBP and TFIIB in Archαeα suggest an early evolutionary origin of the general transcription apparatus of contemporary eukaryotes.

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: May 16, 1994
Published online: May 15, 2008
Issue release date: 1995

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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