Gene Mapping, Cloning, and Sequencing
Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3→p31.3 by nonisotopic in situ hybridizationModi W.S.a · Farrar W.L.b · Howard O.M.Z.c
aBiological Carcinogenesis and Development Program, Program Resources Inc./DynCorp., NCI-Frederick Cancer Research and Development Center; bBiological Response Modifiers Program, NCI-Frederick Cancer Research and Development Center; and cBiological Response Modifiers Program, Program Resources, Inc./Dyncorp, NCI-Frederick Cancer Research and DevelopmentCenter, Frederick, MD (USA)
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JAK1A is a recently isolated class 3 (nonreceptor) tyrosine kinase that has catalytic domain sequence homology with other kinases and is known to be ubiquitously expressed in all human tissues thus far examined. The gene for this enzyme had previously been localized to chromosome 1 using somatic cell hybrids and linkage analyses. In the present study, fluorescence in situ hybridization was utilized to confirm its localization and regionally assign the gene to chromosome region 1p32.3→p31.3.
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