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Gene Mapping, Cloning, and Sequencing

Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2

Sudo K.a,b · Takahashi E.c · Nakamura Y.a,d

Author affiliations

aDepartment of Biochemistry, Cancer Institute, Tokyo, bMitsubishi Kagaku BCL Co. Ltd., Itabashi, Tokyo, cDivision of Genetics, National Institute of Radiological Sciences, Chiba, and dLaboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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Cytogenet Cell Genet 1995;71:385–388

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Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: February 21, 1995
Published online: May 16, 2008
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

We report isolation of human cDNA highly homologous to murine Eif4a2, a gene for one of the protein-synthesis initiation factors involved in the binding of mRNA to the ribosome. This cDNA, which encodes a 407-amino-acid protein, belongs to a highly-conserved gene family, the DEAD-box gene family. The human homologue of Eif4a2 was expressed in all normal tissues examined, but in variable amounts, being highly expressed in skeletal muscle and ovary, and less abundantly in liver, kidney, and pancreas. Furthermore, we have localized the human EIF4A2 to chromosome 18p11.2 by fluorescent in situ hybridization.

© 1995 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Gene Mapping, Cloning, and Sequencing

Accepted: February 21, 1995
Published online: May 16, 2008
Issue release date: 1995

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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