Cytogenetic and Genome Research
Animal Cytogenetics and Comparative Mapping
Cytogenetic effects of advanced maternal age and delayed fertilization on first-cleavage mouse embryosSakurada K. · Ishikawa H. · Endo A.Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Yamagata (Japan)
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Article / Publication Details
Accepted: March 10, 1995
Published online: May 16, 2008
Issue release date: 1996
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
Abstract
It has been shown that both advanced maternal age and delayed fertilization may induce chromosomal anomalies. We therefore examined the combined effects of these two factors on chromosomal anomalies in first-cleavage mouse embryos. We set up normal and (6-h) delayed subgroups in two different age groups (young, 3–4 mo; aged, 9–11 mo) and compared the incidence of chromosomal anomalies. In first cleavage embryos, egg-derived chromosomes can be distinguished from sperm-derived chromosomes. The incidence of maternally derived aneuploidy was highest in the aged-delayed fertilization subgroup. We therefore conclude that advanced maternal age affects the production of aneuploidy more severely when combined with the effect of delayed fertilization.
© 1996 S. Karger AG, Basel
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Article / Publication Details
Accepted: March 10, 1995
Published online: May 16, 2008
Issue release date: 1996
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
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