Trends in Innate Immunity
Editor(s): Egesten, A. (Lund)Schmidt, A. (Witten)
Herwald, H. (Lund)
General Introduction to Innate Immunity: Dr. Jekyl/Mr. Hyde Quality of the Innate Immune SystemZänker K.Institute of Immunology, University Witten/Herdecke, Witten, Germany
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Article / Publication Details
Published online: May 28, 2008
Cover Date: 2008
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8548-4 (Print)
eISBN: 978-3-8055-8549-1 (Online)
Abstract
The innate immunity plays a critical role in host protection against pathogens and transformed cells. It relies amongst others on pattern recognition receptors such as Toll-like receptors, C-type lectin receptors, and nucleotide-binding oligomerization domain proteins to alert and activate defense pathways including the activation of the complement system. Innate immunity represents a trait common to plants and animals, and besides the humoral factors different cell types e.g. subspecies of dendritic cells (plasmacytoid dendritic cells), phagocytic cells, mast cells, glia cells, Kupffer cells, neutrophils and natural killer cells are involved to orchestrate the anti-infectious and antitumor response. Studies in plants, in fruit flies and in mammals reveal that the defensive strategies of invertebrates and vertebrates are highly conserved at the molecular level, which raises the exciting prospects of an increased understanding of innate immunity in a healthy or diseased organism. However, the molecular machinery, e.g. cytokines and chemokines, which triggers, amplifies, and sustains the different phases of the innate immune response could also promote a substantial imbalance between danger and inflammatory response when an infectious challenge is either chronic or not properly declining.
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Article / Publication Details
Published online: May 28, 2008
Cover Date: 2008
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8548-4 (Print)
eISBN: 978-3-8055-8549-1 (Online)
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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