Pharmacology
The Effect of Spironolactone on Antipyrine Metabolism in ManHuffman D.H. · Shoeman D.W. · Pentikäinen P. · Azarnoff L.Clinical Pharmacology and Toxicology Center, Departments of Medicine and Pharmacology, University of Kansas Medical Center, Kansas City, Kans.
Keywords: Antipyrine metabolismSpironolactone |
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Article / Publication Details
Received: June 06, 1973
Published online: May 28, 2008
Issue release date: 1973
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
Spironolactone treatment was associated with a decrease in the plasma antipyrine half-life in all 9 volunteers studied. This was associated with an increased excretion of 4-OH antipyrine but not 3-hydroxymethyl antipyrine in their urine. The plasma antipyrine disappearance rate correlated with the excretion rate of 4-OH antipyrine in the urine. Spironolactone increased the excretion of 6-βOH cortisol in the urine. These data provided indirect evidence that spironolactone is an inducer of hepatic drug hydroxylation in man.
© 1973 S. Karger AG, Basel
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Article / Publication Details
Received: June 06, 1973
Published online: May 28, 2008
Issue release date: 1973
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
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