Pharmacology
The Effect of Aminophylline on Pentagastrin-Induced Secretion and Motor Activity of Totally Isolated Canine Stomach Perfused ExtracorporeallyKowalewski K. · Kolodej A.Surgical-Medical Research Institute and Department of Surgery, the University of Alberta, Edmonton, Alta.
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: November 21, 1975
Published online: May 28, 2008
Issue release date: 1976
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
Totally isolated canine stomachs, perfused extracorporeally with homologous blood of living oxygenator-dogs, were used for the study of gastric secretion. Aminophylline and pentagastrin were infused into the gastric arterial system separately or combined. Aminophylline, infused alone, did not stimulate gastric secretion. However when aminophylline was administered during the infusion of pentagastrin, it significantly augmented the action of this peptide on gastric acid secretion. Aminophylline did not alter myoelectrical and mechanical response to pentagastrin nor did it affect the myoelectrical activity of the nonstimulated stomach. Gastric arterial perfusion pressure and gastric peripheral resistance were reduced during infusion of aminophylline alone or in combination with pentagastrin.
© 1976 S. Karger AG, Basel
Related Articles:
Article / Publication Details
Received: November 21, 1975
Published online: May 28, 2008
Issue release date: 1976
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Get Permission