Pharmacology
Enhancement of the Biological Activity of Adenosine Analogs by the Adenosine Deaminase Inhibitor 2’-DeoxycoformycinAdamson R.H. · Zaharevitz D.W. · Johns D.G.Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Md.
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Article / Publication Details
Received: August 18, 1976
Published online: May 28, 2008
Issue release date: 1977
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
The potent adenosine deaminase inhibitor 2’-deoxycoformycin ((R)-3-(2-deoxy-β-i3-erthyropentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol) inhibits the enzymic inactivation and potentiates the cytotoxic activity of a variety of adenosine analogs in the P388 murine leukemia cell culture system. The activity of all seven adenosine analogs examined was enhanced by 2’-deoxycoformycin with the exception of tubercidin (7-deaza-adenosine) which is not a substrate for the deaminase. In vivo, 2’-deoxy-coformycin potentiated the antineoplastic activity of 9-β-D-xylofuranosyladenine in mice with P388 murine leukemia.
© 1977 S. Karger AG, Basel
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Article / Publication Details
Received: August 18, 1976
Published online: May 28, 2008
Issue release date: 1977
Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
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