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Original Paper

Transport of Model Compounds across the Peritoneal Membrane in the Rat

Torres I.J. · Litterst C.L. · Guarino A.M.

Author affiliations

Department of Surgery, University of Miami Medical School, Biscayne Annex, Miami, Fla., and Laboratory of Toxicology, National Cancer Institute, National Institutes of Heath, Bethesda, Md.

Related Articles for ""

Pharmacology 1978;17:330–340

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 07, 1978
Published online: May 29, 2008
Issue release date: 1978

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The absorption into the systemic circulation of compounds administered intraperitoneally in large volumes was investigated in the rat. The influence on absorption of molecular weight, lipid-water partition coefficient (K), and dissociation constant (pKa) was studied. Nine neutral compounds ranging in molecular weight from 18 to 2 million demonstrated absorptions that decreased with increasing molecular weight. Five compounds were tested with variable lipid partition (K) values (0.001–3.3) and the absorptions increased from 57 to 96% as the K values increased. A series of nine acids and bases covering a wide range of pKa values (0.9–9.9) were investigated. For the acids, absorption increased with increasing pKa value, while for the bases absorption decreased with increasing pKa. For both groups of compounds absorption was directly related to the extent of ionization at physiologic pH. As has been documented for other biological membranes, the peritoneal membrane in the rat was found to behave in a lipoid manner. Unionized or lipid-soluble compounds are absorbed to a greater extent than ionized or lipid-insoluble compounds, and neutral compounds are absorbed in relation to their molecular weights.

© 1978 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 07, 1978
Published online: May 29, 2008
Issue release date: 1978

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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