Pharmacology
Original Paper
Effect of Morphine on ‘Wet-Dog’ Shakes Caused by Cerebroventricular Injection of SerotoninDrust E.G. · Sloviter R.S. · Connor J.D.Department of Pharmacology, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pa.
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Article / Publication Details
Received: October 24, 1978
Accepted: October 26, 1978
Published online: May 29, 2008
Issue release date: 1979
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
Intraventricular administration of serotonin to rats causes ‘wet-dog’ shakes, a sign of morphine withdrawal. The frequency of shakes is dose-dependent. Shaking is potentiated by pretreatment with an inhibitor of monoamine oxidase or with 5,7-dihydroxytryptamine, and is depressed by morphine or serotonin receptor blockers. Depression of serotonin-induced shaking by morphine is reversed rapidly by naloxone. However, naloxone did not reverse the inliibition of ‘wet-dog’ shakes caused by serotonin receptor blockers.
© 1979 S. Karger AG, Basel
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Article / Publication Details
Received: October 24, 1978
Accepted: October 26, 1978
Published online: May 29, 2008
Issue release date: 1979
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Copyright / Drug Dosage / Disclaimer
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