Pharmacology

Original Paper

Propranolol Antagonizes Phencyclidine-Induced Hyperactivity and Stereotypy in Rats

Consroe P. · Boren J.L. · Hsu C.-H.

Author affiliations

Department of Pharmacology and Toxicology, University of Arizona College of Pharmacy, Tucson, Ariz., USA

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Pharmacology 1982;24:96–104

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 06, 1981
Accepted: July 07, 1981
Published online: May 30, 2008
Issue release date: 1982

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The single and combined effects of acute phencyclidine (PCP) and propranolol, each given intraperitoneally, were studied on rat behavior. PCP (5, 10, 25, 50, and 100 mg/kg) produced dose-related stereotypy and increases in (photocell) hyperactivity over 4 h observation. Propranolol (10 and 25 mg/kg) neither caused any stereotypy nor had any effect on activity relative to vehicle control. Additionally, propranolol (10 and 25 mg/kg), given 30 min after PCP (10, 25 and 50 mg/kg), reduced or completely blocked the stereotypy and hyperactivity caused by PCP. These data provide the first experimental verification of a clinical observation that propranolol may be an effective antagonist of the behavioral toxicity produced by PCP.

© 1982 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 06, 1981
Accepted: July 07, 1981
Published online: May 30, 2008
Issue release date: 1982

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


Copyright / Drug Dosage / Disclaimer

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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