Pharmacology
Original Paper
Propranolol Antagonizes Phencyclidine-Induced Hyperactivity and Stereotypy in RatsConsroe P. · Boren J.L. · Hsu C.-H.Department of Pharmacology and Toxicology, University of Arizona College of Pharmacy, Tucson, Ariz., USA
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Article / Publication Details
Received: July 06, 1981
Accepted: July 07, 1981
Published online: May 30, 2008
Issue release date: 1982
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
The single and combined effects of acute phencyclidine (PCP) and propranolol, each given intraperitoneally, were studied on rat behavior. PCP (5, 10, 25, 50, and 100 mg/kg) produced dose-related stereotypy and increases in (photocell) hyperactivity over 4 h observation. Propranolol (10 and 25 mg/kg) neither caused any stereotypy nor had any effect on activity relative to vehicle control. Additionally, propranolol (10 and 25 mg/kg), given 30 min after PCP (10, 25 and 50 mg/kg), reduced or completely blocked the stereotypy and hyperactivity caused by PCP. These data provide the first experimental verification of a clinical observation that propranolol may be an effective antagonist of the behavioral toxicity produced by PCP.
© 1982 S. Karger AG, Basel
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Article / Publication Details
Received: July 06, 1981
Accepted: July 07, 1981
Published online: May 30, 2008
Issue release date: 1982
Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Copyright / Drug Dosage / Disclaimer
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