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Original Paper

Propylthiouracil Disposition in Pregnant and Post-Partum Women

Sitar D.S. · Abu-Bakare A. · Gardiner R.J.

Author affiliations

Divisions of Clinical Pharmacology and Endocrinology, The Montreal General Hospital; Departments of Medicine and of Pharmacology and Therapeutics, McGill University, Montreal, Que., Canada

Related Articles for ""

Pharmacology 1982;25:57–60

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 02, 1981
Accepted: January 21, 1982
Published online: June 04, 2008
Issue release date: 1982

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

Propylthiouracil (PTU) disposition was investigated in hyperthyroid women during pregnancy and post partum. The plasma half-life after the first dose averaged 0.66 h and became greater than 1 h with chronic drug therapy. The apparent volume of distribution after the first dose averaged 0.26 liter/kg, similar to nonpregnant hyperthyroid patients. There was a tendency to increased apparent volume of distribution with chronic drug ingestion. Plasma clearance of PTU showed no change related to disease or to pregnancy. Our data suggest that pregnancy does not have a major effect on the pharmacokinetic disposition of PTU in the hyperthyroid mother. Observation of a prolonged plasma half-life for PTU in 1 patient post partum deserves further investigation to determine if this change is associated with clinically significant therapeutic or toxic effects.

© 1982 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: December 02, 1981
Accepted: January 21, 1982
Published online: June 04, 2008
Issue release date: 1982

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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