Pharmacology

Original Paper

Effect of Theophylline on Thyroid Status in the Rat

Scammell J.G. · Fregly M.J.

Author affiliations

Department of Physiology, College of Medicine, University of Florida, Gainesville, Fla., USA

Related Articles for ""

Pharmacology 1982;25:160–169

Log in to MyKarger to check if you already have access to this content.


Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!


If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.

Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select
* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 29, 1982
Accepted: March 02, 1982
Published online: June 04, 2008
Issue release date: 1982

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The effect of administration of theophylline, thyroxine (T4), or a combination of the two, for 14 days on body weight, food intake, serum concentrations of T4 and 3,5,3’-triiodothyronine (T3), and on the rate of 5’-monodeiodination of T4 to T3 by hepatic and renal homogenates was evaluated. Administration of T4 (25 µg/kg b.w./day) increased the serum concentration of T4 and T4 5’-deiodinase activity. Administration of theophylline (191 mg/kg b.w./day) increased the serum concentration of theophylline to 28.5 µg/ml, increased food intake, but decreased both the concentration of T4 in serum and also T4 5’-deiodinase activity. Administration of a combination of T4 and theophylline returned T4 5’-deiodinase activity to control levels. Since the addition of only high concentrations of theophylline to incubation mixtures inhibited T4 5’-deiodinase directly, it is most likely that the effect of theophylline in vivo on the activity of the T4 5’-deiodinase enzyme is indirect and secondary to inhibition of thyroid hormone secretion.

© 1982 S. Karger AG, Basel




Related Articles:


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 29, 1982
Accepted: March 02, 1982
Published online: June 04, 2008
Issue release date: 1982

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
TOP