Pharmacology
Original Paper
Effect of Theophylline on Thyroid Status in the RatScammell J.G. · Fregly M.J.Department of Physiology, College of Medicine, University of Florida, Gainesville, Fla., USA
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Article / Publication Details
Received: January 29, 1982
Accepted: March 02, 1982
Published online: June 04, 2008
Issue release date: 1982
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
The effect of administration of theophylline, thyroxine (T4), or a combination of the two, for 14 days on body weight, food intake, serum concentrations of T4 and 3,5,3’-triiodothyronine (T3), and on the rate of 5’-monodeiodination of T4 to T3 by hepatic and renal homogenates was evaluated. Administration of T4 (25 µg/kg b.w./day) increased the serum concentration of T4 and T4 5’-deiodinase activity. Administration of theophylline (191 mg/kg b.w./day) increased the serum concentration of theophylline to 28.5 µg/ml, increased food intake, but decreased both the concentration of T4 in serum and also T4 5’-deiodinase activity. Administration of a combination of T4 and theophylline returned T4 5’-deiodinase activity to control levels. Since the addition of only high concentrations of theophylline to incubation mixtures inhibited T4 5’-deiodinase directly, it is most likely that the effect of theophylline in vivo on the activity of the T4 5’-deiodinase enzyme is indirect and secondary to inhibition of thyroid hormone secretion.
© 1982 S. Karger AG, Basel
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Article / Publication Details
Received: January 29, 1982
Accepted: March 02, 1982
Published online: June 04, 2008
Issue release date: 1982
Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Copyright / Drug Dosage / Disclaimer
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