Pharmacology

Original Paper

The Influence of Verapamil on Calcium Transport and Uptake in Segments of Rat Intestine

Pento J.T. · Johnson M.E.

Author affiliations

Division of Pharmacodynamics and Toxicology, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Okla., USA

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Pharmacology 1983;27:343–349

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 07, 1982
Accepted: March 18, 1983
Published online: June 04, 2008
Issue release date: 1983

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The effects of verapamil on calcium transport and uptake in duodenal and jejunal segments of intestine in young male rats were determined using the everted gut-sac technique. Verapamil added to both the mucosal and serosal surface of duodenal segments decreased calcium transport and tissue uptake in a dose-related fashion over a concentration range of 1–2 mM. In jejunal segments verapamil (1 mM) added to both the mucosal and serosal surface reduced calcium transport but did not alter tissue uptake. Similarly, verapamil (1 mM) added to either the mucosal or serosal surface alone in duodenal segments reduced transport but did not depress tissue uptake. The results of this study indicate that verapamil alters calcium translocation in intestinal tissue in a fashion which is similar to that reported in other biological tissue.

© 1983 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 07, 1982
Accepted: March 18, 1983
Published online: June 04, 2008
Issue release date: 1983

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


Copyright / Drug Dosage / Disclaimer

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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