Pharmacology

Original Paper

Effects of Ethylketocyclazocine on Adrenergic Transmission in the Isolated Perfused Cat Spleen

Gaddis R.R. · Dixon W.R.

Author affiliations

Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, Kans., USA

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Pharmacology 1985;30:205–214

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 20, 1984
Accepted: August 24, 1984
Published online: June 04, 2008
Issue release date: 1985

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The pre- and postsynaptic effects of ethylketocyclazocine (EKC), a putative κ opiate receptor agonist, on sympathetic adrenergic neurotransmission were investigated using the isolated perfused cat spleen. Perfusion of spleens with EKC (10–7 and 10–6M) produced a modest dose-dependent inhibition of nerve-stimulation-mediated overflow of norepinephrine (NE) and total 3H. In contrast, EKC (10–4M) produced an increase in the release of NE, and total 3H overflow. Perfusion with EKC (10–5 and 10–4M) resulted in a dose-dependent inhibition of the postsynaptic response to stimulation-mediated release of NE. Likewise, EKC inhibited splenic contraction due to exogenously administered NE which was not antagonized by naloxone. These results suggest that EKC exerts a direct effect on peripheral adrenergic neurotransmission not mediated via classical k opiate receptors.

© 1985 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 20, 1984
Accepted: August 24, 1984
Published online: June 04, 2008
Issue release date: 1985

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


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