Pharmacology
Original Paper
Effects of Acute and Chronic Morphine Administration on Glucose Tolerance in MiceChan M.-Y. · Dai S.Department of Pharmacology, Faculty of Medicine, University of Hong Kong
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Article / Publication Details
Received: July 03, 1986
Accepted: September 21, 1986
Published online: June 05, 2008
Issue release date: 1987
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
The effects of acute and chronic morphine treatment on glucose tolerance were investigated in mice. In acute experiments, a single dose of morphine (20 mg/kg i.p.) increased the serum and muscle glucose level. After glucose loading (1.5 g/kg), the rate of increase and the peak of serum glucose concentration were significantly lowered in morphine-treated mice, while the availability and the half-life of glucose were similar to those of controls. In morphine-dependent mice, the fasting serum and muscle glucose levels were similar to those of control but the liver glucose was significantly greater. After glucose loading the rate of increase in serum glucose level was faster and the availability of glucose was 10% greater than that in naive mice. Again, there was no difference in the half-life of serum glucose between naive and morphine-dependent mice.
© 1987 S. Karger AG, Basel
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Article / Publication Details
Received: July 03, 1986
Accepted: September 21, 1986
Published online: June 05, 2008
Issue release date: 1987
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Copyright / Drug Dosage / Disclaimer
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