Pharmacology

Original Paper

Effects of Acute and Chronic Morphine Administration on Glucose Tolerance in Mice

Chan M.-Y. · Dai S.

Author affiliations

Department of Pharmacology, Faculty of Medicine, University of Hong Kong

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Pharmacology 1987;34:233–240

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 03, 1986
Accepted: September 21, 1986
Published online: June 05, 2008
Issue release date: 1987

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

The effects of acute and chronic morphine treatment on glucose tolerance were investigated in mice. In acute experiments, a single dose of morphine (20 mg/kg i.p.) increased the serum and muscle glucose level. After glucose loading (1.5 g/kg), the rate of increase and the peak of serum glucose concentration were significantly lowered in morphine-treated mice, while the availability and the half-life of glucose were similar to those of controls. In morphine-dependent mice, the fasting serum and muscle glucose levels were similar to those of control but the liver glucose was significantly greater. After glucose loading the rate of increase in serum glucose level was faster and the availability of glucose was 10% greater than that in naive mice. Again, there was no difference in the half-life of serum glucose between naive and morphine-dependent mice.

© 1987 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 03, 1986
Accepted: September 21, 1986
Published online: June 05, 2008
Issue release date: 1987

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


Copyright / Drug Dosage / Disclaimer

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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