Pharmacology
Original Paper
Effect of the New Zinc Compound Beta-Alanyl-L-Histidinato Zinc on Bone Metabolism in Elderly RatsYamaguchi M. · Ozaki K.Department of Environmental Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
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Article / Publication Details
Received: October 12, 1989
Accepted: July 31, 1990
Published online: June 05, 2008
Issue release date: 1990
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
The effect of a new zinc compound β-alanyl-L-histidinato zinc (AHZ) on bone metabolism was investigated in aged rats (30 weeks old). AHZ (1.0, 2.5 and 7.5 mg/100 g body weight) was orally administered to rats 3 times at 24-hour intervals, and the rats were bled 24 h after the last administration. The administration of AHZ (7.5 mg/l00 g) did not cause an appreciable alteration of calcium and inorganic phosphorus concentrations in the serum, and zinc, calcium and deoxyribonucleic acid contents in the femoral diaphysis were significantly increased by the administration of AHZ (7.5 mg/100 g). The bone alkaline phosphatase activity was significantly increased by doses of 1.0–7.5 mg AHZ/100 g. These results suggest that AHZ has a stimulatory effect on bone formation and calcification in aged rats.
© 1990 S. Karger AG, Basel
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Article / Publication Details
Received: October 12, 1989
Accepted: July 31, 1990
Published online: June 05, 2008
Issue release date: 1990
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Copyright / Drug Dosage / Disclaimer
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