Mismatch Negativity and N100 in Comatose PatientsFischer C.a · Morlet D.b · Giard M.-H.b
aClinical Neurophysiology Unit, EA1880, Neurological Hospital, and bINSERM U280, Mental Process and Brain Activation, Lyon, France
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Mismatch negativity (MMN) and N100 auditory evoked potential were recorded in 52 healthy subjects and in 128 severely comatose patients. The MMN was present in 33/128 patients and N100 in 84/128. A ratio of 30/33 patients with MMN and 70/84 with N100 regained consciousness in a mean time of 6.3 ± 4 days after the recording session. Thus, in terms of predicting return to consciousness, the MMN was more specific (90.9%) than the N100 (57.6%), but its sensitivity was lower (31.6% for MMN and 73.7% for N100, respectively). The amplitudes of MMN and N100 in comatose patients were smaller than those of healthy subjects. It is concluded that MMN and N100 can be very useful in predicting whether or not a comatose patient will regain consciousness.
© 2000 S. Karger AG, Basel
- Atienza M, Cantezro JL, Gomez CM: The mismatch negativity component reveals the sensory memory during REM sleep in humans. Neurosci Lett 1997;237:21–24.
- Cant BR, Hume AL, Judson JA, Shaw NA: The assessment of severe head injury by short-latency somatosensory and brain-stem auditory evoked potentials. Electroencephalogr Clin Neurophysiol 1986;65:188–195.
- Fischer C, Morlet D, Bouchet P, Luauté J, Jourdan C, Salord F: Mismatch negativity (MMN) and late auditory evoked potentials in comatose patients. Clin Neurophysiol 1999;110:1601–1610.
- De Giorgio CM, Rabinowicz AL, Gott PS: Predictive value of P300 event-related potentials compared with EEG and somatosensory evoked potentials in non-traumatic coma. Acta Neurol Scand 1993;87:423–427.
- Giard MH, Perrin F, Pernier J: Brain generators implicated in processing of auditory stimulus deviance: A topographic ERP study. Psychophysiology 1990;27:627–640.
- Gott PS, Rabinowicz AL, De Giorgio CM: P300 auditory event-related potentials in nontraumatic coma. Arch Neurol 1991;48:1267–1270.
- Greenberg RP, Newlon PG, Hyatt MS, Narayan RK, Becker DP: Prognostic implications of early multimodality evoked potentials in severely head-injured patients. J Neurosurg 1981;55:227–236.
- Joutsiniemi SL, Ilvonen T, Sinkkonen J, Huotilainen M, Tervaniemi M, Lehtokoski A, Rinne T, Näätänen R: The mismatch negativity for duration decrement of auditory stimuli in healthy subjects. Electroencephalogr Clin Neurophysiol 1998;108:154–159.
Kane NM, Curry SH, Butler SR, Cummins BH: Electrophysiological indicator of awakening from coma. Lancet 1993;341:688.
- Kane NM, Curry SH, Rowlands CA, Manara AR, Lewis T, Moss T, Cummins BH, Butler SR: Event-related potentials – Neurophysiological tools for predicting emergence and early outcome from traumatic coma. Intensive Care Med 1996;22:39–46.
- Litscher G: Middle latency auditory evoked potentials in intensive care patients and normal controls. Int J Neurosci 1995;83:253–267.
- Loewy DH, Campbell KB, Bastien C: The mismatch negativity to frequency deviant stimuli during natural sleep. Electroencephalogr Clin Neurophysiol 1996;98:493–501.
- Morlet D, Bouchet P, Fischer C: Mismatch negativity and N100-monitoring: Potential clinical value and methodological advances. Audiol Neurootol 2000;5:198–206.
Näätänen R: Attention and Brain Function. Hillsdale, Erlbaum, 1992.
- Näätänen R: The mismatch negativity: A powerful tool for cognitive neuroscience. Ear Hear 1995;16:6–18.
Pekkonen E, Jousmäki V, Partanen J, Karhu J: Mismatch negativity area and age-related auditory memory. Electroencephalogr Clin Neurophysial 1993;87:321–325.
- Rosenberg C, Wogensen K, Starr A: Auditory brain-stem and middle- and long-latency evoked potentials in coma. Arch Neurol 1984;41:835–838.
Schröger E: A neural mechanism for involuntary attention shifts to changes in auditory stimulation. J Cogn Neurosci 1996;8:527–539.
Signorino M, D’Acunto S, Angeleri F, Pietropaoli P: Eliciting P300 in comatose patients. Lancet 1995;345:255–256.
- Tiitinen H, May P, Reinikainen K, Näätänen R: Attentive novelty detection in humans is governed by pre-attentive sensory memory. Nature 1994;372:90–92.
- Van Hooff JC, de Beer NAM, Brunia CHM, Cluitmans PJM, Korsten HHM: Event-related potential measures of information processing during general anesthesia. Electroencephalogr Clin Neurophysiol 1997;103:268–281.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.