Pharmacology
Original Paper
Effect of Volatile General Anesthetics and n-Alcohols on Glutamate- Stimulated Increases in Calcium Ion Flux in Hippocampal Membrane VesiclesDaniell L.C.Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, Ga., USA
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Article / Publication Details
Received: August 12, 1994
Accepted: October 27, 1994
Published online: June 10, 2008
Issue release date: 1995
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
Abstract
N-Methyl D-aspartate (NMDA) receptor activity was determined by measurement of L-glutamate-stimulated increases in free intracellular calcium concentrations (Cai) in membrane vesicles isolated from mouse hippocampi. Incubation with anesthetic concentrations of the volatile general anesthetics, halothane, enflurane, and diethyl ether, inhibited NMDA responses. The n-alcohols, ethanol, propanol, butanol and pentanol inhibited NMDA receptor responses, but methanol was ineffective. The ability of volatile anesthetics and n-alcohols to inhibit NMDA responses appears to be unrelated to the ability of some of these agents to increase resting Cai since no correlation occurred between the two effects. The results of this study show that hippocampal NMDA receptors are sensitive to inhibition by volatile general anesthetics and n-alcohols. This effect may, in part, underlie their anesthetic effects in vivo.
© 1995 S. Karger AG, Basel
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Article / Publication Details
Received: August 12, 1994
Accepted: October 27, 1994
Published online: June 10, 2008
Issue release date: 1995
Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 0
ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)
For additional information: https://www.karger.com/PHA
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