Pharmacology

Original Papers

Biliary Cefpiramide Excretion: Its Relation to Biliary Excretion of Bile Acids and Sulfobromophthalein

Takikawa H. · Uchida Y. · Sano N. · Yamanaka M.

Author affiliations

Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan

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Pharmacology 1995;51:24–32

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Article / Publication Details

First-Page Preview
Abstract of Original Papers

Received: December 02, 1994
Accepted: February 03, 1995
Published online: June 10, 2008
Issue release date: 1995

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA

Abstract

Cefpiramide, a β-lactam antibiotic, has been reported to be excreted from hepatocytes into the bile by a carrier-mediated system. Herein, the relationship of biliary cefpiramide excretion to the excretion of bile acids and sulfobromophthalein was studied in rats. Biliary cefpiramide excretion was markedly inhibited by sulfobromophthalein, lithocholate-3-O-glucuronide and taurolithocholate-3-sulfate, whereas it was not inhibited by ursodeoxycholate or taurocholate. However, the inhibitory effect of cefpiramide on the biliary excretion of sulfobromophthalein or lithocholate-3-sulfate was very small. These findings indicate that, although cefpiramide is excreted by a process common to organic anions and bile acid sulfate and glucuronide, two or more excretory pathways for organic anions exist and cefpiramide has affinity for only one of these carriers.

© 1995 S. Karger AG, Basel




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Article / Publication Details

First-Page Preview
Abstract of Original Papers

Received: December 02, 1994
Accepted: February 03, 1995
Published online: June 10, 2008
Issue release date: 1995

Number of Print Pages: 9
Number of Figures: 0
Number of Tables: 0

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: https://www.karger.com/PHA


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