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Original Paper

Postnatal Somatic Growth and Insulin Contents in Moderate or Severe Intrauterine Growth Retardation in the Rat

Garofano A. · Czernichow P. · Bréant B.

Author affiliations

INSERM U457, Hôpital Robert-Debré, Paris, France

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Biol Neonate 1998;73:89–98

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 16, 1998
Issue release date: February 1998

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

A rat model of perinatal malnutrition was designed to study the role of nutrition in postnatal somatic growth and insulin stores until adulthood. Maternal food restriction (50%) from day 15 of pregnancy resulted in intrauterine growth retardation (IUGR) in the offspring. The outcome of moderate or severe IUGR was investigated. Neonates with moderate IUGR normally nourished postnatally showed normal body and organ weights and normal insulin contents in adulthood. Offspring with severe IUGR normally nourished postnatally also rapidly recovered normal body and pancreatic weights, but liver and kidney weights were significantly reduced at adult age. Malnutrition until weaning in offspring with severe IUGR induced marked growth retardation (50%) in body and organ weights at weaning. Although pancreatic weight recovered at adult age, body, liver and kidney weights were irreversibly affected, despite several months of normal nutrition. Furthermore, severe IUGR at birth resulted in decreased insulin content at adult age, irrespective of postnatal nutrition. In conclusion, this animal model demonstrates that normalization of adult size can be dissociated from organ growth and also that altered insulin stores in adulthood are more dependent on the severity of IUGR at birth than on postnatal catch-up in organ growth.


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 16, 1998
Issue release date: February 1998

Number of Print Pages: 10
Number of Figures: 4
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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