Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

Ramadan Fasting and the GH/IGF-1 Axis of Trained Men during Submaximal Exercise

Bouhlel E.a · Zaouali M.b · Miled A.c · Tabka Z.b · Bigard X.d · Shephard R.e

Author affiliations

aInstitut Supérieur du Sport et de l’Education Physique, Gafsa, and bLaboratoire de Physiologie, Faculté de Médecine Ibn el Jazzar and cLaboratoire de Biochimie, Hôpital Farhat Hached, Sousse, Tunisia; dCentre de Recherches du Service de Santé des Armées, La Tronche, France; eFaculty of Physical Education and Health, University of Toronto, Toronto, Ont., Canada

Related Articles for ""

Ann Nutr Metab 2008;52:261–266

Do you have an account?

Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information












By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.


I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 05, 2007
Accepted: June 25, 2007
Published online: July 10, 2008
Issue release date: September 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM

Abstract

Aims: The aim of this study was to explore possible changes in body composition, blood glucose regulation, plasma growth hormone (GH), insulin-like growth factor 1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3), and insulin concentrations of trained athletes in response to the intermittent fasting and dehydration of Ramadan observance. Methods: Nine trained male rugby players (age 19 ± 2 years, height 1.78 ± 0.74 m) were tested 3 times: before Ramadan (C), at the end of the first week (R1), and during the fourth week (R2). They performed a progressive cycle ergometer test at each visit. The work rate was increased in 6-min stages corresponding to 20, 30, 40, 50 and 60% of &Wdot; max. Substrate oxidation was evaluated by indirect calorimetry. On each occasion, substrate and plasma hormone concentrations were measured at rest and at the end of the exercise. Results: Ramadan fasting induced a significant decrease in body mass and body fat (R2 vs. C, p < 0.001). Plasma concentrations of glucose, insulin, GH, IGF-1 and IGFBP-3 did not change significantly between C and R2, either at rest or following exercise. Conclusion: Ramadan fasting induces positive changes in body composition without disturbing glucose regulation or activity of the GH/IGF-1 system.

© 2008 S. Karger AG, Basel


References

  1. Zaccaria M, Varnier M, Piazza P, Noventa D, Ermolao A: Blunted growth hormone response to maximal exercise in middle-aged versus young subjects and no effect of endurance training. J Clin Endocrinol Metab 1999;84:2303–2307.
  2. Kanaley JA, Weltman JY, Pieper KS, Weltman A, Hartman ML: Cortisol and growth hormone responses to exercise at different times of day. J Clin Endocrinol Metab 2001;86:2881–2889.
  3. Holt RIG, Webb E, Pentecost C, Sönksen PH: Aging and physical fitness are more important than obesity in determining exercise-induced generation of GH. J Clin Endocrinol Metab 2001;86:5715–5720.
  4. Jenkins PJ: Growth hormone and exercise. Clin Endocrinol (Oxf) 1999;50:683–689.
  5. Eliakim A, Brasel JA, Mohan S, Barslow T, Berman N, Cooper DM: Physical fitness, endurance training and the growth hormone-insulin-like growth factor I system in adolescent females. J Clin Endocrinol Metab 1996;81:3986–3992.
  6. Kanaley JA, Weltman JY, Veldhuis, JD, Rogol AD, Hartman ML, Weltman A: Human growth hormone responses to repeated bouts of aerobic exercise. J Appl Physiol 1997;83:1756–1761.
  7. Manetta J, Brun JF, Maimoun L, Callis A, Prefaut C, Mercier J: Effect of training on the GH/IGF-1 axis during exercise in middle-aged men: relationship to glucose homeostasis. Am J Physiol Endocrinol Metab 2002;283:E929–E936.
  8. Aimaretti G, Colao A, Corneli G, Pivonello R, MacCario M, Morrison K, Pflaum CD, Strasburger CJ, Lombardi G, Ghigo E: The study of spontaneous GH secretion after 36-h fasting distinguishes between GH-deficient and normal adults. Clin Endocrinol (Oxf) 1999;51:771–777.
  9. Maccario M, Aimaretti G, Grottoli S, Gauna C, Tassone F, Corneli G, Rossetto R, Wu Z, Strasburger CJ, Ghigo E: Effects of 36 hour fasting on GH/IGF-I axis and metabolic parameters in patients with simple obesity. Comparison with normal subjects and hypopituitary patients with severe GH deficiency. Int J Obes Relat Metab Disord 2001;25:1233–1239.
  10. Chen JW, Hojlund K, Beck-Nielsen H, Sandahl Christiansen J, Orskov H, Frystyk J: Free rather than total circulating insulin-like growth factor-I determines the feedback on growth hormone release in normal subjects. J Clin Endocrinol Metab 2005;90:366–371.
  11. Hartman ML, Veldhuis JD, Johnson ML, Lee MM, Alberti KGMM, Samojlik E, Thorner MO: Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two day fast in normal men. J Clin Endocrinol Metab 1992;74:757–765.
  12. Ho PJ, Friberg RD, Barkan AL: Regulation of pulsatile growth hormone secretion by fasting in normal subjects and patients with acromegaly. J Clin Endocrinol Metab 1992;75:812–819.
  13. Bogdan A, Bouchareb B, Touitou Y: Ramadan fasting alters endocrine and neuroendocrine circadian patterns. Meal-time as a synchronizer in humans? Life Sci 2001;68:1607–1615.
  14. Durnin JVGA, Womerslay J: Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr 1974;32:77–97.
  15. Brandou F, Dumortier M, Garandeau P, Mercier J, Brun JF: Effects of two-month rehabilitation program on substrate utilization during exercise in obese adolescents. Diabetes Metab 2003;29:20–27.
  16. Wasserman K, Hansen JE, Sue DY, Whipp BJ: Principles of Exercise Testing and Interpretation. Philadelphia, Lea & Febiger, 1986.
  17. Winer LM, Shaw MA, Baumann G: Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion. J Clin Endocrinol Metab 1990;70:1678–1686.
  18. Surya S, Symons K, Rothman E, Barkan AL: Complex rhythmicity of growth hormone secretion in humans. Pituitary 2006;9:121–125.
  19. Van Cauter E, Kerkhofs M, Caufriez A, Van Onderbergen A, Thorner MO, Copinschi G: A quantitative estimation of growth hormone secretion in normal man: reproducibility and relation to sleep and time of day. J Clin Endocrinol Metab 1992;74:1441–1450.
  20. Fedail SS, Murphy D, Salih SY, Bolton CH, Harvey RF: Changes in certain blood constituents during Ramadan. Am J Clin Nutr 1982;36:350–353.
  21. Sweileh N, Schnitzler A, Hunter GR, Davis B: Body composition and energy metabolism in resting and exercising Muslims during Ramadan fast. J Sports Med Phys Fitness 1992;72:156–163.
  22. Leiper JB, Molla AM, Molla AM: Effects on health of fluid restriction during fasting in Ramadan. Eur J Clin Nutr 2003;57:S30–S38.
  23. Poehlman ET, Turturro A, Bodkin N, Cefalu W, Heymsfield S, Holloszy J, Kemnitz J: Caloric restriction mimetics: physical activity and body composition changes. J Gerontol A Biol Sci Med Sci 2001;56:45–54.
  24. Poortmans JR: Protein metabolism; in Poortmans JR (ed): Principles of Exercise Biochemistry. Basel, Karger, 2004, pp 186–229.
  25. Bouhlel E, Salhi Z, Bouhlel H, Mdella S, Amamou A, Zaouali M, Mercier J, Bigard X, Tabka Z, Zbidi A, Shephard RJ: Effect of Ramadan fasting on fuel oxidation during exercise in trained male rugby players. Diabetes Metab 2006;32:617–624.
  26. Megia A, Herranz L, Luna R, Gomez-Candela C, Pallardo F, Gonzalez-Gancedo P: Protein intake during aggressive calorie restriction in obesity determines growth hormone response to growth hormone- releasing hormone after weight loss. Clin Endocrinol (Oxf) 1993;39:217–220.
  27. Bang P, Brismar K, Rosenfeld RG, Hall K: Fasting affects serum insulin-like growth factors (IGFs) and IGF-binding proteins differently in patients with noninsulin-dependent diabetes mellitus versus healthy nonobese and obese subjects. J Clin Endocrinol Metab 1994;78:960–967.
  28. Knapig JJ, Merideth CN, Jones BH, Suek L, Young VR: Influence of fasting on carbohydrate and fat metabolism during rest and exercise in men. J Appl Physiol 1988;64:1923–1929.
  29. Nieman DC, Carlson KA, Brandstater ME, Naegele RT, Blankenship JA: Running endurance in 27-hour fasted humans. J Appl Physiol 1987;63:2502–2509.
  30. Nemet D, Connolly PH, Pontello-Pescatello AM, Rose-Gottron C, Larson JK, Galassetti P, Cooper DM: Negative energy balance plays a major role in IGF-1 response to exercise training. J Appl Physiol 2004;96:276–282.
  31. Forbes GB, Brown MR, Welle SI, Underwood IE: Hormonal response to overfeeding. Am J Clin Nutr 1989;49:608–611.
  32. Ross RJ: GH, IGF-1 and binding proteins in altered nutritional states. Int J Obes Relat Metab Disord 2000;24:892–895.
  33. Katz LE, DeLeon DD, Zhao H, Jawad AF: Free and total insulin-like growth factor (IGF-1) levels decline during fasting: relationships with insulin and IGF-binding protein-1. J Clin Endocrinol Metab 2002;87:2978–2983.
  34. Roky R, Houti I, Moussamih S, Qotbi S, Aadil N: Physiological and chronobiological changes during Ramadan intermittent fasting. Ann Nutr Metab 2004;48:296–303.
  35. Schwartz AJ, Brasel JA, Hintz RL, Mohan S, Cooper DM: Acute effect of brief low- and high-intensity exercise on circulatory insulin-like growth factor (IGF) I, II and IGF-binding protein-3 and its proteolysis in young healthy men. J Clin Endocrinol Metab 1996;81:3492–3497.
  36. Wideman L, Weltman JY, Hartman ML, Veldhuis JD, Weltman A: Growth hormone release during acute and chronic aerobic and resistance exercise; recent finding. Sports Med 2002;32:987–1004.
  37. Bengtsson B, Eden S, Lonn L, Kvist H, Stokland A, Lindstedt G, Bosaeus I, Tolli J, Sjostrom L, Isaksson OG: Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1992;76:309–313.
    External Resources
  38. Johannson G, Marin P, Lonn L, Ottosson M, Stenlof K, Bjorntorp P, Sjostrom L, Bengtsson B: Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 1996;82:727–732.
  39. Johannson G, Grimby G, Sunnerhagen KS, Bengtsson B: Two years of growth hormone (GH) treatment increase isometric and isokinetic muscle strength in GH-deficient adults. J Clin Endocrinol Metab 1997;82:2877–2883.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 05, 2007
Accepted: June 25, 2007
Published online: July 10, 2008
Issue release date: September 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: https://www.karger.com/ANM


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.