Blood Purification

Original Paper

Reduced Blood bcl-2 Protein Concentration in Patients on Hemodialysis

Buemi M.a · Allegra A.a · Corica F.a · Ruello M.a · Di Pasquale G.b · Aloisi C.a · Giaccobe M.S.a · Romeo A.a · Frisina N.a

Author affiliations

a Cattedra di Nefrologia II, Dipartimento di Medicina Interna, b Istituto di Clinica Pediatrica, Policlinico Universitario di Messina, Italia

Keywords: Apoptosis, bcl-2 proteinChronic renal failureHemodialysisLipoperoxidationOxidative stress

Related Articles for ""
Blood Purif 1998;16:312–316
https://doi.org/10.1159/000014350

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: May 14, 1999
Issue release date: November – December

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

Abstract

The concentrations of bcl-2 protein that can block programmed cellular death in various cell lines were evaluated in blood samples from 10 uremic patients on hemodialysis, 10 uremics not yet on hemodialysis, and in 10 healthy controls. The bcl-2 protein variations (in uremics on dialysis) were ascertained in patients during the dialysis session. Oxidative stress was evaluated in all groups by assaying the products of intraerythrocytic lipoperoxidation. Dialyzed and nondialyzed uremic patients had higher bcl-2 protein concentrations than healthy subjects. Dialysis causes a significant reduction in the concentrations of bcl-2 protein which becomes statistically significant during the 3rd hour. In both groups of uremic patients a positive correlation was found between bcl-2 protein and products of lipoperoxidation.



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References

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: May 14, 1999
Issue release date: November – December

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: https://www.karger.com/BPU

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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1998, Vol.16, No. 6

November – December

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