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Original Paper

First-Episode Psychosis: Diagnostic Stability over One and Two Years

Haahr U.a · Friis S.b, c · Larsen T.K.f · Melle I.b · Johannessen J.O.f · Opjordsmoen S.b, c · Simonsen E.a · Rund B.R.d · Vaglum P.e · McGlashan T.g

Author affiliations

aPsychiatric Research Unit, Zealand Region Psychiatry Roskilde, Roskilde, Denmark; bUllevaal University Hospital and Departments of cPsychiatry, dPsychology, and eBehavioral Sciences in Medicine, University of Oslo, Oslo, fStavanger University Hospital, Haugesund Hospital, Stavanger, Norway; gDepartment of Psychiatry, Yale University, New Haven, Conn., USA

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Psychopathology 2008;41:322–329

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 23, 2007
Accepted: October 22, 2007
Published online: July 19, 2008
Issue release date: August 2008

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: https://www.karger.com/PSP

Abstract

Background: Diagnostic stability is important for daily clinical work and planning of treatment. The aims of this study were to measure diagnostic stability in a clinical epidemiologic sample and to identify markers of change in diagnosis. Sampling and Methods: Diagnostic stability and change were measured in a sample of 301 patients with first-episode psychosis from four national health care sectors in Norway and Denmark at baseline, 1 and 2 years. Results: Diagnostic stabilities were high for schizophrenia and schizoaffective disorder (85–99%), low for schizophreniform disorder (16–19%), and intermediate for other diagnoses. Diagnostic change from schizophreniform to schizophrenia was frequent in year 1 (72%). Characteristics discriminating schizophreniform patients keeping their diagnosis (i.e. having recovered within 6 months with no relapse) from those developing schizophrenia at 1 year were female gender, better childhood premorbid functioning, shorter duration of untreated psychosis and more severe general psychotic symptoms, especially excitation. Conclusions: Findings provide validation for the DSM-IV categories within the schizophrenic spectrum. The limitations of the study were: the raters were not blind to baseline assessments; patients with longer duration of untreated psychosis were more likely to refuse participation; not all patients were assessed at 1- and 2-year follow-up, but the attrition was rather low.

© 2008 S. Karger AG, Basel


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    External Resources
  26. Friis S, Melle I, Larsen TK, Haahr U, Johannessen JO, Simonsen E, Opjordsmoen S, Vaglum P, McGlashan TH: Does duration of untreated psychosis bias study samples of first-episode psychosis? Acta Psychiatr Scand 2004;110:286–291.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 23, 2007
Accepted: October 22, 2007
Published online: July 19, 2008
Issue release date: August 2008

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 3

ISSN: 0254-4962 (Print)
eISSN: 1423-033X (Online)

For additional information: https://www.karger.com/PSP


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