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Personalized Nutrition for the Diverse Needs of Infants and Children

62nd Nestlé Nutrition Workshop, Pediatric Program, Helsinki, September 2007

Editor(s): Bier D.M. (Houston, Tex.) 
German J.B. (Davis, Calif.) 
Lönnerdal B. (Davis, Calif.) 
Cover

Genetically Determined Variation in Polyunsaturated Fatty Acid Metabolism May Result in Different Dietary Requirements

Koletzko B.a · Demmelmair H.a · Schaeffer L.a,b · Illig T.b · Heinrich J.b

Author affiliations

aDivision of Metabolic Diseases and Nutritional Medicine, Dr. von Hauner Children’s Hospital, University of Munich, Munich, b Helmholtz Institute of Epidemiology, Neuherberg, Germany

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Bier DM, German JB, Lönnerdal B (eds): Personalized Nutrition for the Diverse Needs of Infants and Children. Nestec Ltd., Vevey/S. Karger AG, Basel, © 2008. Nestlé Nutr Workshop Ser Pediatr Program, vol 62, pp 35-49

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: July 15, 2008
Cover Date: 2008

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8553-8 (Print)
eISBN: 978-3-8055-8554-5 (Online)

Abstract

Tissue availability of polyunsaturated fatty acids (PUFAs) is of major relevance for health, and it depends on both dietary intake and metabolic turnover. We found close associations between variants in the human genes of Δ5- and Δ6-desaturase, FADS1 and FADS2, and serum phospholipid contents of PUFAs and long-chain PUFAs (LCPUFAs). Polymorphisms and reconstructed haplotypes of FADS1 and the upstream region of FADS2 showed strong associations with levels of the n-6 LC-PUFA arachidonic acid (20:4n-6). Carriers of the less common polymorphisms and their respective haplotypes also had a lower prevalence of allergic rhinitis and atopic eczema. Our data demonstrate for the first time that the fatty acid composition of serum phospholipids is genetically controlled by the FADS1 FADS2 gene cluster. The investigated single nucleotide polymorphisms in this cluster explain 28% of the variance of serum phospholipid arachidonic acid and up to 12% of its precursor acids. Based on this genetic variation, individuals may require different amounts of dietary PUFAs or LC-PUFAs to achieve comparable biological effects. We strongly recommend including analyses of FADS1 and FADS2 polymorphism in future cohort and intervention studies addressing the biological effects of PUFAs and LC-PUFAs, which should enhance the sensitivity and precision of such studies.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: July 15, 2008
Cover Date: 2008

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8553-8 (Print)
eISBN: 978-3-8055-8554-5 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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