Personalized Nutrition for the Diverse Needs of Infants and Children
62nd Nestlé Nutrition Workshop, Pediatric Program, Helsinki, September 2007
Editor(s): Bier, D.M. (Houston, TX)German, J.B. (Davis, CA)
Lönnerdal, B. (Davis, CA)
Individual Epigenetic Variation: When, Why, and So What?Gomes M. · Waterland R.Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine,
USDA Children’s Nutrition Research Center, Houston, TX, USA
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Article / Publication Details
Published online: July 15, 2008
Cover Date: 2008
Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8553-8 (Print)
eISBN: 978-3-8055-8554-5 (Online)
Abstract
Epigenetics provides a potential explanation for how environmental factors modify the risk for common diseases among individuals. Interindividual variation in DNA methylation and epigenetic regulation has been reported at specific genomic regions including transposable elements, genomically imprinted genes and the ‘inactive’ X chromosomes in females. We currently have a very poor understanding of the factors that contribute to interindividual epigenetic variation. In particular, it is important to understand when during the life cycle epigenetic variation arises, why epigenetic regulation varies among individuals, and whether epigenetic interindividuality affects susceptibility to diet-related chronic disease. In this review we will summarize current progress toward answering these questions.
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Article / Publication Details
Published online: July 15, 2008
Cover Date: 2008
Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0
ISBN: 978-3-8055-8553-8 (Print)
eISBN: 978-3-8055-8554-5 (Online)
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